Synthesis, characterisation and biological aspects of copper. These goldi dithiocarbamate complexes show in vitro cytotoxic activities against a549 human lung carcinoma, hela human cervical cancer and mcf7 human breast cancer cell lines. Us9492465b2 us15042,852 us201615042852a us9492465b2 us 9492465 b2 us9492465 b2 us 9492465b2 us 201615042852 a us201615042852 a us 201615042852a us 9492465 b2 us9492465 b2 us 9492465b2 authority us united states prior art keywords complexes au gold complex bu prior art date 20140319 legal status the legal status is an assumption and is not a legal conclusion. Pdf synthesis and characterization of homoleptic group. A standard dimeric zinc dithiocarbamate structural motive, a rare cadmium dithiocarbamate coordination polymer, and a hydrated sodium. Dithiocarbamates dtcs are versatile chelating ligands with. Dithiocarbamate ligands have shown very good binding ability by forming complexes with most transition and main group metals 1,2. It is the analog of a carbamate in which both oxygen atoms are replaced by sulfur atoms when only 1 oxygen is replaced the result is thiocarbamate. Jul 17, 2019 all the complexes have been characterized using elemental analysis, infrared and nmr 1 h and c spectroscopies and x. Request pdf main group dithiocarbamate complexes dithiocarbamates, r2ncss. These complexes are active against several cancer cells, with the most active compound able to act against ten cancer cells in vitro and with gi50 as low as 0. Antioxidant activities of the dithiocarbamate salts and their coiii complexes were also investigated using dpph assay and the complexes were found to be more efficient. A series of new dithiocarbamate complexes of niii, pdii and ptii of the form nil 2, pdl 2 and ptl 2 where l nethylnethanoldithiocarbamate have been synthesized and characterized by elemental analysis, ftir, and 1 h and c nmr spectroscopy. Significant attention has been given to organotiniv dithiocabamate compounds in recent times.
Synthesis, structural characterization, and antibacterial activity of novel erbiumiii complex containing antimony. Dithiocarbamate assembly on gold journal of the american. Synthesis and characterization of copperii dithiocarbamate complexes involving pyrrole and ferrocenyl moieties and their utility for sensing anions and preparation of copper sulfide and copperiron sulfide nanoparticles. Molecules free fulltext chemistry and some biological. Three dithiocarbamate complexes with europium, eus2cnrr3l, where l 1,10phenanthroline, and r methyl, r ethyl 1, r r npropyl 2, and r r ibutyl 3, as well as the lanthanide complexes, lns2cnr23 l, where r ethyl, l. Cyclopentadienyl dithiocarbamate and dithiophosphate. Us20150266909a1 goldi complexes with tbutyl phosphine. Dithiocarbamate fungicides were evaluated several times by the jmpr for toxicology and residues. Synthesis, characterization and electrochemical studies of coii, iii dithiocarbamate complexes article pdf available in journal of coordination chemistry 725. Synthesis and characterization of homoleptic group 10 dithiocarbamate complexes and heteroleptic niii complexes, and the use of the homoleptic niii for the preparation.
Pdf synthesis and characterization of homoleptic group 10. Synthesis, characterization and the use of organotiniv. Au surfaces are functionalized by stable dithiocarbamate ligands when exposed to carbon disulfide and secondary amines. The majority of the complexes studied have simple r 1 and r 2 groups, such as methyl, ethyl and phenyl. Aspects of its precursors uses to synthesize adducts, nanoparticles, and nanocomposites are reported. Synthesis and characterization of copperii dithiocarbamate. Chemistry and some biological potential of bismuth and antimony dithiocarbamate complexes. M pt and pd dithiocarbamate complexes is synthesized and characterized by spectroscopic methods and singlecrystal xray diffraction. Selenidomolybdenumv dithiocarbamate complexes springerlink. It is the analog of a carbamate in which both oxygen atoms are replaced by sulfur atoms when only 1 oxygen is replaced the result is thiocarbamate a common example is sodium diethyldithiocarbamate. Dithiocarbamate article about dithiocarbamate by the free.
Synthesis, characterization and electrochemical studies of. Cid 3001860 dithiocarbamic acid expand this section. Pdf metal complexes of dithiocarbamate derivatives and its. Synthesis and characterization of homoleptic group 10. Synthesis and characterization of homoleptic group 10 dithiocarbamate complexes and heteroleptic niii complexes, and the use of the homoleptic niii for the preparation of nickel sulphide nanoparticles. Thermal characterization studies on zinc, cadmium and. Analysis of dithiocarbamate fungicides in vegetable. Furthermore, transition metal dithiocarbamate complexes, prepared from a diverse range of new ligands, have been the focus of. Nickelii dithiocarbamate complexes containing the pyrrole. The alkyl r groups on the n atoms of dithiocarbamates could be varied with different organic groups such as alkyl and aryl derivatives. The detailed study 1518 of various dithiocarbamates and their derivatives through infrared spectra confirms the contribution of various forms equally to the structure. In vitro antibacterial and anticancer activity of znii iopscience. The readily available binding sites of the two sulphur atoms within the dithiocarbamate moiety in the complexes confers a wide variety of geometry. Synthesis, characterisation and biological aspects of.
Density functional theory study of goldiiidithiocarbamate. Mulkey, director signed office of pesticide programs 7501c to. Dithiocarbamate dtc fungicides are a group of organosulfur compounds represented by a general structure r1r2 nc ssx, where r can be substituted by an alkyl, alkylene, aryl or similar other group, and x is usually a metal ion, widely used in agriculture and frequently detected as pesticide residues in plant products in the world. The reaction is a highly atomeconomic process for production of salkyl thiocarbamates. For their metabolite ethylenethiourea etu, an adi of 0 0. Evaluation of the stability constant for the complexes between the metal and dmdc indicate that copper is the only metal that is most likely to inhibit the transformation reactions under conditions. The adsorbed dithiocarbamates are robust under a wide ph range and can resist displacement by other chemisorptive surfactants, providing an attractive method for conjugating sensitive molecules onto metal surfaces. We have synthesized a series of lanthanide dithiocarbamate precursors for the synthesis of lanthanide sulfide materials and nanoparticles. Synthesis, characterization and antifungal studies by botha nandipha loveness 200904696 b. Monomeric ruthenium dithiocarbamate complexes were also prepared as model compounds and their spectroscopic data compared with those of the metallodendrimers.
Effect of metal complexation on the degradation of. Both ironii and ironiii complexes were synthesised, the latter being a facile, open bench reaction producing a range of fes2cnrr3 complexes. Us9492465b2 goldi complexes with tbutyl phosphine and. The novel compounds were characterized using nmr spectroscopy 1h and c and mass spectrometry. Synthesis and characterization of light lanthanide. A large number of analogs of cisplatin have been tested, and it has been reported that many active complexes could react with cell dna and inhibit its synthesis 11 14. The cui dithiocarbamates are pale yellow to reddishyellow diamagnetic solids and their melting points decrease with increasing size of the alkyl groups on the ligands. Interest in the synthesis of biiii and sbiii dithiocarbamate complexes is on the rise, and this has been attributed to their wide structural diversity and their interesting application as biological agents and in solid statematerials chemistry. On the synthesis, properties, and applications of metal. The significant among several canonical forms for the dithicarbamates in their metal complexes, ms 2cnr 2n are as follows. Built on an ethos of openness, we are passionate about working with the global academic community to promote open scholarly research to the world. Induced properties of heteroleptic copperi xanthatedithiocarbamate pph 3 complexes gunjan rajput department of chemistry, faculty of science, banaras hindu university, varanasi 221005, india, fax.
Pdf chemistry 211 synthesis, characterization and biological. Monomeric ruthenium dithiocarbamate complexes were also prepared as model compounds and their spectroscopic data compared with those of the. A dithiocarbamate is a functional group in organic chemistry. The disubstituted dithiocarbamates of cuii are stable, water insoluble compounds and under acidic conditions do.
Studies on some dioxouraniumvi complexes with dithiocarbamate ligands. A range of metal dithiocarbamate complexes were synthesised and chapter 2 focusses on the synthesis of iron dithiocarbamates. Iii dithiocarbamate complexes is on the rise, and this has been. Induced properties of heteroleptic copperi xanthatedithiocarbamate pph 3 complexes gunjan rajput. Iron dithiocarbamate complexes may easily bind free no radicals to form a stable mononitrosyl iron complex. Progresses made in previous researches on syntheses of dithiocarbamates led to increase in further researches. Density functional theory study of goldiiidithiocarbamate complexes with characteristic anticancer potentials. A highly efficient, mild and simple synthesis of dithiocarbamates is based on the onepot reaction of amines, cs 2, and alkyl halides without using a catalyst under solventfree conditions. A continuous mass loss was observed in both ligand complexes of mercury and only 10% initial mass remained at 650c, owing to the volatile nature of mercury dithiocarbamates. A series of bimetallic dppfmii dppf 1,1bis diphenyphosphino ferrocene. These complexes have been characterized by elemental analysis, molecular weight measurements, ir and nmr 1 h, c and 119 sn spectroscopy, suggesting that the methyl tin complexes are probably four coordinate, while the phenyl tin ones are probably fivecoordinate with bidentate dithiocarbamate. May 03, 2005 au surfaces are functionalized by stable dithiocarbamate ligands when exposed to carbon disulfide and secondary amines. Phosphinogoldi complexes, featuring heterocycle dithiocarbamate ligands, have been synthesized and characterized. Cdpadtc 2 complexes and the final residue was found to be cds.
Two new zinc and dithiocarbamate integrated metal complexes such as. This is due to their ability to stabilize specific stereochemistry in. Synthesis and structural characterization of bismuthiii. Chlorodiphenyltiniv dithiocarbamate complexes as chemodosimeters and host for anions and neutral compounds in solution. These complexes also serve as useful precursors for different metal sulfide nanoparticles. Complexes with dithiocarbamate ligands having functional substituted organic groups, such as r 1 and or r 2 equal to ch 2 ch 2 oh, are increasingly being studied, with crystal structures reported for a number of metal complexes including those of alkali metals copper, nickel,, zinc, mercury and antimony. Pdf chemistry and some biological potential of bismuth. Both complexes 1 and 2 are isostructural having linear geometry. The complexes adopt cisoctahedral geometry with folded macrocyclic ligand and with the dithiocarbamate bound as a bidentate. Department of chemistry, faculty of science, banaras hindu university, varanasi 221005, india, fax. Huang, syntheses, crystal structures and antibacterial activities of dithiocarbamate complexes mmebnncs. Honours chemistry ufh being a dissertation submitted to the faculty of science and agriculture in fulfilment of the requirements for the award of the degree of. Abstract monosubstituted dithiocarbamate complexes of light lanthanides of the type rnhcss4lnnbun4nh2o where r dbnd ph, pmeph. No dithiocarbamatecomplexes trade name applications 1.
All the complexes have been characterized using elemental analysis, infrared and nmr 1 h and c spectroscopies and x. Coiii n,ndiarylformamidine dithiocarbamate complexes. A new complex of znii that contain amino acid valine and dithiocarbamate. Dithiocarbamates and their derivatives are widely used in the vulcanization of rubber.
Thermal characterization studies on zinc, cadmium and mercury. Syntheses, characterization, and antimicrobial properties of nickelii dithiocarbamate complexes containing nis4 and nis2pn moieties. Synthesis and characterization of light lanthanide complexes. Spectral studies show that the dithiocarbamate group. Density functional theory study of goldiii dithiocarbamate complexes with characteristic anticancer potentials. Pdf chemistry and some biological potential of bismuth and. Dithiocarbamate article about dithiocarbamate by the.
The significant among several canonical forms for the dithicarbamates in. Apr 20, 2018 synthesis and characterization of copperii dithiocarbamate complexes involving pyrrole and ferrocenyl moieties and their utility for sensing anions and preparation of copper sulfide and copperiron sulfide nanoparticles. Thermal characterization, zinc, cadmium and mercury dithiocarbamate complexes. Their discovery was early in the field of sulfur chemistry, with their applications as vulcanisation accelerators and fungicides being explored not long after. M ni, cu, pd, zn, n 10, 18 were reported by hoshinomiyajima, 790 who found that derivatives bound to ni, cu, and pd were mesomorphic, showing both nematic and smc mesophases at elevated temperatures, i. The reaction is a highly atomeconomic process for production of s alkyl thiocarbamates. Therefore, irondithiocarbamates may be used to scavenge free no. Synthesis, characterization, and xray crystal structures of znii and hgii complexes and their use as precursors for metal sulfide nanoparticles. Dithiocarbamatefunctionalized dendrimers as ligands for. The determination of whether dithiocarbamate pesticides share a common mechanism of toxicity from. The synthesized goldiii dithiocarbamate complexes were tested for their in vitro cytotoxic activity towards an array of human tumor cell lines and were noted to be 1 to 4fold more cytotoxic than cisplatin 12. Download hires image download to mspowerpoint cite this. Thus, the protective action of the dithiocarbamate against the toxicity of cisplatin seems to be the formation of its stable platinum dithiocarbamate complexes 7, 10.
Synthesis, structural and antibacterial study of some metal ion. Nickelii dithiocarbamate complexes containing the pyrrole moiety for sensing anions and synthesis of nickel sulfide and nickel oxide nanoparticles e. With the help of our academic editors, based in institutions around the globe, we are able to focus on serving our authors while. The molecular structures of the dithiophosphate complex moh5c 5 me 5cl 3 h 2s 2 poet 2 and the peroxo derivative moh5c 5 h 5. Analysis of dithiocarbamate fungicides in vegetable matrices. Metal dithiocarbamate complexes possess many interesting and useful properties which has made them ubiquitous in the literature. Pdf synthesis, characterization and electrochemical studies. Effect of metal complexation on the degradation of dithiocarbamate fungicides. Synthesis, spectra, crystal structures and anticancer.
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